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The accelerated healing of bone fracture using low-intensity pulsed ultrasound (LIPUS) has been medically practiced in recent years. Bone formation is considered to be associated with the piezoelectricity in bone. Therefore, to enhance fracture healing by ultrasound irradiation, it is important to sufficiently understand the piezoelectric properties at ultrasound frequencies in bone, particularly, in cancellous bone which is metabolically active. The author has experimentally observed the piezoelectric signal generated in bone using an ultrasound sensor, called as “piezoelectric cell (PE-cell)”, in which an air-saturated bone specimen was adopted as a piezoelectric oscillator. In this study, the frequency dependence of the piezoelectric signal was investigated. The piezoelectric signals could be observed at 1 to 5 MHz, and the variation in the piezoelectric sensitivity with frequency was not significant. Considering the fact that the ultrasound attenuation in cancellous bone can increase largely with frequency, it appeared that the observed piezoelectric signals could be generated at the trabecular elements close to the surface of the bone specimen.
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