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For the particles below 100 nm, very low backscatter amplitudes are produced, but the larger particles ranging between 200 and 500 nm, the nanoparticles (i.e. nano-contrast agent) produces significant subharmonic and harmonic components of the backscatter spectrum. Consequent upon this, the feasibility of using solid nanoparticles as ultrasound contrast agent below 100 nm have been called into question on the ground that the size of a nano-particle is much smaller than the wavelength of ultrasonic wave, therefore, backscattering from these particles would obviously be poor and hence, poor poor image quality. An appropriate size metal nanoparticles exhibit some important properties, such as, bio-conjugation and enhanced permeability retention (EPR) effect. We assume that on account of enhanced permeability and retention effect, the solid nanoparticles accumulate at the site of interest to ensure high local concentrations, this would enhance image brightness and quality. In present work, we have synthesized solid nano-particles of gold to study its applications as ultrasound contrast agent (USCA). Size of the nanoparticles were estimated with the help of XRD which turned out to become nearly 10 nm (9.7 nm). The results suggest that with existing ultrasound technology, it appears that gold nano-particles of size 10 nm may not be suitable as contrast agent for ultrasound imaging as it failed to improve image brightness or image quality.
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