Abstracts Submitted: 510
Number of Users: 710
View Abstracts Submitted
Back to home Page
In this article, we have reported the interaction between levofloxacin and surfactant with particular focus on the interaction mechanism and physico-chemical properties of the yielding CTAB-drug aggregates. Densities and speeds of sound of CTAB (cetyltrimethylammonium bromide) in aqueous solutions of levofloxacin (0.001, 0.005, and 0.01 mol∙kg-1) have been measured at different temperature (293.15 - 313.15 K) at an interval of 5 K. The thermo-acoustical and compressibility parameters such as adiabatic compressibility , , specific acoustical impedance, , intermolecular free length, , relative association, , molar sound number , , have been obtained from the experimental data for CTAB in different solutions of levofloxacin at different temperatures. These parameters have been further provide reasonable estimate for the critical micellar concentration of the surfactant, the affinity or binding constant for the interaction of drug with an equivalent micellar structure and the loading capacity of the equivalent micellar structure. These observations are potentially significant for drug formulation of poorly bioavailable drugs in pharmaceutical industries.
© Copyright 2017 All Rights Reserved